In addition, Kaplan-Meier analysis revealed a significant association between shorter overall survival in ESCC patients and high expression of cyclin D1 (n = 204, P = 0.049, log-rank test, Fig. 7d), or MMP14 (n = 196, P = 0.0062, log-rank test; Fig. 7e). This evidence concerns the gene CCND1 and esophageal squamous cell carcinoma.