More precise data regarding the time point at which anti-flotillin-1/2 is induced, and the phenotype relation and the prevalence have to be assembled in large cohorts of patients with inflammatory demyelinating CNS disorders including CIS; acute disseminated encephalomyelitis; NMOSD, each with and without ON; and isolated ON in order to discern the diagnostic, therapeutic, and prognostic value of these autoantibodies. The gene discussed is FLOT1; the disease is in situ carcinoma.