However, Western blot analysis of aqueous humor and vitreous samples showed an increase in IL6 downstream effectors (Fig. 3b), p-STAT3 (9.26 fold, p < 0.01) and p-Erk1/2 (3.84 fold, p < 0.01) after retinal detachment (RD1). Here, MAPK3 is linked to retinal detachment.