In addition to exposure to GDM, several factors such as ethnicity, family history of T2DM, multiparity, advanced maternal age, treatment with insulin, presence of anthropometric risk factors (pre-pregnancy and postpartum BMI, weight gain during pregnancy) and high blood sugar levels (fasting, 1 hour and 2 hour glucose levels on OGTT) in the index pregnancy have been identified as predictors of later development of T2DM [13,14,15,16,17,18,19,20,21,22]. This evidence concerns the gene INS and type 2 diabetes mellitus.