To examine further detail of the roles of these secretory glycoproteins at the late stage of viral life cycle, intracellular infectivity and specific infectivity (infectious titers/viral RNA levels) in the supernatant were determined in BE-KO cells expressing HA-ApoE, HA-Erns, and Hel derived from CSFV, or HA-NS1 derived from DENV serotypes 3 and 4 at 72-h post-infection with HCV (Fig 7A and 7B). The gene discussed is APOE; the disease is infection.