CASP3 and colonic neoplasm: Another study on ilimaquinone and an ilimaquinone analogue (ethylsmenoquinone) showed that these compounds were able to induce G2/M cell cycle arrest and increase apoptosis by caspase-3 cleavage and autophagy; this mechanism was stimulated by both compounds through microtubule-associated protein 1 light chain 3 (LC3) in HCT116 colon cancer cells [184].