TP53 and neoplasm: The persistent decrease in glucose uptake was not entirely surprising, as others have reported, both in vitro and in mice-bearing tumor xenografts, no difference in Fluoro-2-deoxyglucose uptake between HCT116 cells with wild–type p53 versus the HCT116 p53 null cells (Wang et al., 2007), suggesting that p53 is not solely responsible for suppression of glucose uptake, and that other factors likely contribute.