TP53 and neoplasm: For instance, glycolytic enzymes such as PFK and LDHA have been shown to be essential for driving tumor formation and growth (Fantin et al., 2006; Le et al., 2010; Yalcin et al., 2009), and tumor suppressor genes such as p53 are emerging as primary regulators of energy production (Bensaad et al., 2006; Cheung and Vousden, 2010; Hu et al., 2010).