VHL and nonpapillary renal cell carcinoma: To consolidate the potential role of VHL in cell sensitivity to anthracyclines, doxorubicin, with vincristine as a control, was applied to a series of ccRCC cell lines, including VHL-deficient RCC4, 786-O, A498 and 769-P, as well as VHL-proficient Caki-1, Caki-2, OS-RC-2, HK-2 and ACHN31.