Three of the four naïve 2K2 (0.59%), 6N1 (0.71%), and CB52 (0.41%) and three of the four immune BP71 (0.53%), BS14 (0.46%), and MA071 (0.52%) macaques had detectable IFN-γ response to ZIKV infection on day 30; and on day 60 we were still able to detect a small response in one naïve 2K2 (0.31%) and two immune BP71 (0.34%) and MA071 (0.42%) macaques. The gene discussed is IFNG; the disease is Zika virus infectious disease.