In line with this, enhanced endogenous binding of mutant vWF to GPIbα in patients with vWF disease-type 2B results in giant platelets and thrombocytopenia and was reported to be associated with dysregulation of the LIM kinase/cofilin pathway in MKs, together with upregulated RhoA signalling42. This evidence concerns the gene CFL1 and Thrombocytopenia.