Interestingly, our experiments showed that both catalase and the NF‐κB inhibitor Bay11‐7082 suppressed diabetes‐induced up‐regulation of the autophagy proteins beclin‐1 and LC3‐II, raising the possibility that the nuclear translocation of p65 may modulate the transcription of BECN1, resulting in the subsequent dysregulation of autophagy in the diabetic mice heart. Here, RELA is linked to diabetes mellitus.