HSPA5 and Alzheimer disease: 2002; Hoozemans et al. 2005, 2009; Unterberger et al. 2006; Stutzbach et al. 2013). The levels of BiP, PERK‐P and IRE1‐P in AD neurons correlate with the observed Braak stages, a neuropathological method for determining the levels neurofibrillary tangles and phosphorylated tau (Hoozemans et al. 2009; Duran‐Aniotz et al. 2017), indicating that the UPR is involved in AD pathology at an early stage.