Neither ablation nor overexpression of wild-type PNPLA3 affects the liver fat content in mice, whereas transgenic mice with hepatic specific overexpression of human 148M or PNPLA3 I148M knock-in mice exhibit increased hepatic TAG contents and LD sizes and develop hepatic steatosis (Basantani et al., 2011, Li et al., 2012, Pirazzi et al., 2012, Smagris et al., 2015). This evidence concerns the gene PNPLA3 and Hepatic steatosis.