NAFLD seems to be associated with altered hepatokines production such as fetuin-A, fibroblast growth factor-21 (FGF-21), selenoprotein P, sex hormone-binding globulin (SHBG), angiopoietin-related growth factor (AGF) and leukocyte derived chemotaxin 2 (LECT2) (Lebensztejn et al., 2016). The gene discussed is FGF21; the disease is metabolic dysfunction-associated steatotic liver disease.