It was reported that the inhibition of EZH2 may be a potential therapeutic strategy to target GBM proliferation, migration, and angiogenesis as the inhibition of EZH2 in vitro by pre-miR-101, EZH2 siRNA, or small molecule DZNep attenuated GBM cell growth, migration/invasion, and GBM-induced endothelial tubule formation in a U87-Fluc-mCherry GBM xenograft mouse imaging model resulted in a reduced tumor growth and migration/invasion. Here, EZH2 is linked to glioblastoma.