Trebicka et al. reported increased miR-122 which was positively correlated with serum transaminases during early stages of fibrosis but was negatively correlated in late stages; they concluded that loss of hepatocytes and progression of fibrosis resulted in drop of serum miR-122 levels [23], while Bihrer et al. found that serum miR-122 levels were comparable between CHC patients with normal ALT levels and healthy controls [24]. The gene discussed is GPT; the disease is cryohydrocytosis.