GPT and Cirrhosis: The aim of the present study was first to assess the diagnostic value of plasma miR-122 and miR-21 in Egyptian patients with chronic hepatitis C virus genotype-4 to detect liver fibrosis/cirrhosis development in comparison to other noninvasive indices (APRI) aspartate aminotransferase to platelet ratio index, and aspartate aminotransferase to Alanine Aminotransferase Ratio (AAR).