Together with the previous findings (Fahrer et al., 2014; Lai et al., 2014) and our current analyses showed that CDT reduces autophagy-related molecules, including LC3-II, Beclin1, and HMGB1, indicating that CDT renders radioresistant PCa cells sensitive to radiation may be attributed to the induction of DSB and suppression of the autophagy pathway. The gene discussed is HMGB1; the disease is isolated focal cortical dysplasia type II.