MAPT and Alzheimer disease: For example, methylene blue enhances proteasomal degradation and improves cognitive function in a mouse model of AD,102 and methylene blue also enhances autophagy and thereby suppresses Tau pathology in models relevant to FTD.58 Dietary energy restriction (DER), which is known to stimulate autophagy, is neuroprotective in animal models of AD and PD (see ref.30 for review).