Enhances recruitment of primed T cells to inflamed tissue and entry of naïve T cells to lymphoid organs (54).Fever alone increases leukocyte extravasation through gp130 dependent mechanisms (92).IL-6 trans-signaling as well as signaling initiated by other IL-6 family members increase l-selectin expression by T cells through ERK1/2 activation and increase their extravasation (93, 94).IL-6 trans-signaling increases vascular expression of both adhesion the molecules (e.g., ICAM-1, VCAM-1, CD62E, and release of chemoattractant (CCL2, CXCL10, CCL4, CCL5, CCL11, and CCL17) (95). This evidence concerns the gene CCL4 and Fever.