IL6 and graft versus host disease: IL-6 blockade as prophylaxis against GVHD has been investigated in only one study (155), where a single dose of tocilizumab 8 mg/kg (maximum dose 800 mg) was added to standard GVHD prophylaxis with cyclosporine A and methotrexate in 48 patients that underwent T-cell replete allotransplantation with myeloablative or reduced intensity conditioning regimes.