INS and obesity due to melanocortin 4 receptor deficiency: Glucose tolerance: Obesity/glucose intolerance is associated with low-grade chronic inflammation and high baseline IL-6 levels (104). Insulin treatment reduces IL-6 levels (105, 106). IL-6 secreted by adipocytes seems to favor the development of anti-inflammatory M2 (107). Inhibition of the mIL-6R in the liver is associated with reduced glucose tolerance and dyslipidemia (108).