The proliferative chondrocytes in the growth plates of the LWD patients’ fore-/hind-limb zeugopods are highly disrupted, and it is noteworthy that the zeugopodial SHOX expression in embryonic human limb buds is spatially corresponding to the defect in LWD patients (6–11). This evidence concerns the gene SHOX and Leri-Weill dyschondrosteosis.