TP53 and hepatocellular carcinoma: Furthermore, while Yibin Feng (Wang et al., 2011) has reported the autophagic effect of fangchinoline, via p53/sestrin2/AMPK signaling in human hepatocellular carcinoma cells, we are the first group demonstrating the autophagic effect of tetrandrine through PKC-α inhibition and mTOR inhibition in breast cancer cells, which is independent of AMPK, ROS and sestrin2 signaling pathway.