Administration of DCI could reestablish an adequate tissue content of DCI derivatives, increase insulin sensitivity and improve ovulatory frequency and serum androgens and/or levels of lipid biomarkers in women affected by PCOS (Nestler et al., 1999; Iuorno et al., 2002; Kawa et al., 2003; Cheang et al., 2008). The gene discussed is INS; the disease is polycystic ovary syndrome.