Interestingly, a sub-set analysis of PCOS women with fasting insulin levels above 12 μU/mL revealed that they experienced a greater reduction of both fasting insulin plasma levels and area under the curve (AUC) of insulin under OGTT compared to patients with fasting insulin levels below 12 μU/mL (Genazzani et al., 2012). This evidence concerns the gene INS and polycystic ovary syndrome.