Investigating an Alzheimer's disease (AD) mouse model [transgenic for five familial AD (5XFAD) mutations associated with the Amyloid precursor protein (APP) and Presenilin 1], as well as brain samples from AD patients, Jung and colleagues reported a reduction in SIRT6 protein in these models (Jung et al., 2016). The gene discussed is PSEN1; the disease is Alzheimer disease.