The upregulation of NEP correlates with ongoing EMT as tumor cells with significant expression of EMT markers, such as vimentin and α-smooth muscle actin (αSMA), and S100 proteins show increased levels of CD10 on the cell surface (94% atypical fibroxanthoma, 50% of squamous cell carcinoma, and 33% of spindle cell/desmoplastic melanomas) [77, 78]. Here, MME is linked to squamous cell carcinoma.