Instead, HDAC1 and DNMT1, the main known HDAC and DNMT factors in cancer have highest expression in hematopoietic malignancies, especially the B-cell lymphoma in the pan-cancer expression analysis (cBioportal, Supplementary Fig. 2) which may be the reason of the effectiveness of HDACi and DNMTi in treating these cancers. Here, DNMT1 is linked to cancer.