GSK3B and acute kidney injury: In fact, previous studies have shown that GSK3 inhibition can attenuate fibroblast activation and fibrosis development following renal IRI in mice.30 Given that previous studies have shown that chronic alcohol exposure results in GSK3β activation in the liver and brain,31, 32, 33 we hypothesized that GSK3 may be involved in the impact of chronic alcohol intake on the consequences of AKI.