ACTA1 and acute kidney injury: However, mice with IR-induced AKI exhibited enhanced collagen-1 and fibronectin deposition as well as α-SMA expression at 14 days post IR compared with sham controls (ANOVA, surgery main and interaction effects, F(1,28)=26.47–31.02, P<0.0001; Tukey’s test, P<0.05; Figures 3a and b).