SNAI1 and Ureteral obstruction: Specifically, pharmacological GSK3 inhibition attenuates TGFβ1-mediated signaling and ECM accumulation in cultured renal glomerular mesenchymal cells and in lung, gingival, corneal and skin fibroblasts.66, 67, 68, 69, 70 In contrast, other studies have shown that GSK3 inhibition increases TGFβ1-induced β-catenin and Snail accumulation in a unilateral ureteral obstruction model and renal epithelial cells in vitro.