We observed nominal associations at rs801733 (CNIH2, p = 0.026, OR = 0.428) and rs11066008 (MYL2-CUX2 (ALDH2), p = 2.94 × 10−3, OR = 0.666) (Table 1), which are in strong LD with the previously identified gout associated variants (rs4073582 and rs671, r2 = 0.96 and 0.79, respectively), and the directions of effects for both variants were consistent with the previous reports14, 22. This evidence concerns the gene ALDH2 and gout.