CNIH2 and gout: The conditional analysis indicated seven independent variants for the gout associated loci: rs1260326 (L446P) of GCKR, rs11722228 of SLC2A9, rs12505410 and rs2231142 (Q141K) of ABCG2, rs4073582 of CNIH2, rs671 (E504K) of ALDH2 (MYL2-CUX2) and rs9895661 of BCAS3 (Supplementary Table S7), thus we only included these independent variants in the cumulative genetic risk score analysis.