NFE2L2 and congenital hereditary endothelial dystrophy of cornea: While the expression of SLC4A11 (mutated in these tissues) did not show a major change, there was significant reduction in expression of NRF2 (Fig. 7b) accompanied by reduced expression of HO-1, ferritin (FRT), GR, and to some extent of NQO1 in CHED patients (Fig. 7c).