While the expression of SLC4A11 (mutated in these tissues) did not show a major change, there was significant reduction in expression of NRF2 (Fig. 7b) accompanied by reduced expression of HO-1, ferritin (FRT), GR, and to some extent of NQO1 in CHED patients (Fig. 7c). Here, HMOX1 is linked to congenital hereditary endothelial dystrophy of cornea.