SLC7A2 and infection: Initially, we employed a RNA interference-based strategy to assess the effect of the down-modulation of the gene encoding CAT2A/B on infection by P. berghei. To this end, Huh7 cell lines stably expressing shRNA sequences targeting the SLC7A2 gene were generated and their infection by luciferase-expressing P. berghei parasites was compared with that of control cells 48 h after parasite addition.