MTMR3 inhibition through miR-100 activates p27 that can either turn on apoptosis through Bax/Bcl-2 or G2/M cell cycle arrest through CDK1/Cyclin B. An analysis of human PCa samples by Leite et al. revealed a global de-regulation of miR-100-5p during the transition from high grade localized PCa to metastasis37. This evidence concerns the gene BCL2 and posterior cortical atrophy.