For example, a variant of CDKN2B-AS1 significantly contributes to risk of fetal growth restriction [67], both FLT1 [68] and LPL [69] are significantly differentially expressed in placental tissues from pregnancies with intrauterine growth restriction (IUGR), and preeclampsia and LDLR-deficient mice had litters with significant IUGR [70]. The gene discussed is LDLR; the disease is preeclampsia.