For highly-ranked genes (according to the number of significant associations present within the 12 populations) in Fig 1B such as BCAS3, CNNM2, TEX41, SMG6 and PHACTR1, the consistent overlap between selection and genetic risk of CAD suggests that many of these may have been modified by CAD-linked selective pressures. This evidence concerns the gene TEX41 and coronary artery disorder.