ALOX12 and Familial prostate cancer: Expression of 12-lipoxygenase, the enzyme involved in generation of 12(S)-HETE, is correlated with more malignant stages of prostate cancer [57,58]; 12(S)-HETE is a well-known endo-agonist ligand of TRPV1, shown to increase the firing rate of sensory neurons via activation of the TRPV1 channel opening [59].