RUNX1 and acute myeloid leukemia: The RUNX1-RUNX1T1 (AML-ETO), a pathological fusion protein containing the amino-terminal 177 amino acids of AML1 and the carboxyl-terminal 575 amino acids of RUNX1T1 is generated from a t(8;21) translocation that disrupts normal hematopoiesis [50].