Following establishment of the association between rs10774671 and SS susceptibility, we further determined the influence of different genotypes on the alternative splicing of OAS1. Four isoforms of OAS1 are annotated in the NCBI Reference Sequence (RefSeq; http://www.ncbi.nlm.nih.gov/refseq) database, of which we analyzed p46, p42, and p48, and p44, an un-annotated isoform previously reported in RNA-sequencing (RNA-seq) studies [54–56] (Fig 3B). Here, OAS1 is linked to synovial sarcoma.