AFP and neoplasm: Univariate analysis showed that total bilirubin ≤14 μmol l−1, α-fetoprotein (AFP) >400 ng ml−1, tumour size >5 cm, tumour cell thick trabecular arrangement, portal vein tumour thrombus, higher tumour node metastasis (TNM) stage, and HBc mutations in E77, P79, E83, L84 and S87 were associated with shorter OS.