Recently, our data also showed FUT4 was crucial regulators of cancer response to chemotherapy in breast cancer and hepatocellular carcinoma, as well as of invasiveness and tumorigenicity in breast cancer.27, 29, 30 Thus, miR-26a/26b-induced FUT4 provided a conserved mechanism for the suppressive role of miR-26a/26b during aggressiveness of CRC. This evidence concerns the gene FUT4 and breast cancer.