FUT4 and breast cancer: FUT4 was highly expressed in gastric cancer tissues and serum, respectively as compared to chronic gastritis and gastric ulcer.18 FUT4 was a novel regulator of epithelial–mesenchymal transition (EMT), which was a crucial step in tumor progression in breast cancer cells.19 FUT4 was also overexpressed in most of metastatic colorectal cancer patients and associated with poorer outcomes.20 In our previous studies, the altered level of FUT4 was responsible for changed drug-resistant phenotypes of human hepatocellular carcinoma (HCC) cell lines BEL7402 and BEL/FU cells both in vitro and in vivo.