Resistance to apoptosis is a hallmark of cancer and the attenuation of such capacity might be a valuable anticancer therapy strategy.29 For instance, tumors often increase the expression of anti-apoptotic regulators, such as Bcl-2 and related protein family, and inhibit the expression of pro-apoptotic factors, such as Bax, and caspase-3. Here, CASP3 is linked to cancer.