CDK5 and B-cell chronic lymphocytic leukemia: By immunoblotting, we observed that CDK5 and its activator p35 are overexpressed in a panel of lymphoma cell lines, including DLBCL (Figures 1a–c), Hodgkin lymphoma, Burkitt lymphoma, and chronic lymphocytic leukemia cell lines (Supplementary Figure S1a) compared to B lymphocytes.