Then, in order to demonstrate that the effect of miR-26a on proliferation and apoptosis of DLBCL was mediated by p35 and consequently modulation of CDK5 activity, we generated new cell lines: starting from SU-DHL-8, we created a control line (E.V.), a cell line overexpressing miR-26a (miR-26/E.V). This evidence concerns the gene CDK5 and diffuse large B-cell lymphoma.