A number of research groups have shown that glucose condition was related to chemosensitivity.44, 45 Interestingly, gene expression data set analysis from the online database BioGPS (http://biogps.org/) showed that glucose regulates AQP9 expression level depending on KRAS status in CRC cells (GEO: GSE31084). Here, AQP9 is linked to colorectal carcinoma.