Modulation of aquaporins’ function or expression could have therapeutic potential in many diseases, including cancer.11, 12 Studies have shown that AQP3, another aquaglyceroporin, was involved in cell proliferation and may be attributed to tumor initiation.13, 14, 15 Evidence showed that AQP9 has a vital role in modulating arsenite sensitivity in leukemia.16, 17 The role of AQP9 in regulating chemosensitivity in CRC warrants further investigation. Here, AQP9 is linked to colorectal carcinoma.