No evidence of UCP2 mutations between the two strains was obtained in our previous study.23 In the attempt to unravel, at least in part, some of the mechanisms underlying brain UCP2 downregulation upon JD in the stroke-prone strain, we searched for mechanisms involved in the translational regulation of UCP2. As a result, we found that the UCP2 expression modulation upon JD in the brains of SHRSP and SHRSR was related to the microRNA-503. The gene discussed is UCP2; the disease is Stroke.