FERMT2 and esophageal squamous cell carcinoma: Cells with dynamic assembly of cytoskeleton and active focal adhesion with the surrounding microenvironment are predisposed to local invasion and distant metastasis.33 Kindlin-2, a FERM domain containing protein, has been shown to modulate cell migration via interactions with the cytoskeleton, resulting in cell–extracellular matrix adhesions in human cancers including ESCC.21, 22, 34, 35, 36, 37 Furthermore, overexpression of Kindlin-2 was observed in the invasive front of malignant mesothelioma38 and breast cancer,35 whereas knockdown of Kindlin-2 exerts tumor-suppressive roles.