As described for non-malignant cells (see ‘MYBL2 in cell cycle regulation’ section), MYBL2 has also been shown to drive cell proliferation and/or cell cycle progression in cancer cells, such as breast cancer,111 cervical cancer,112 colorectal cancer,89 hepatocellular carcinoma,91 leukemic cells,15 lung adenocarcinoma42 and neuroblastoma (in MYCN-amplified cell lines).113. The gene discussed is MYBL2; the disease is hepatocellular carcinoma.