MAP2K7 and melanoma: Other examples of adaptive resistance include melanoma cells switching to a NGFRhigh state upon exposure to RAF/MEK inhibitors [108], NSCLC cells upregulating ZEB1 on prolonged exposure to increasing concentrations of erlotinib [109], vemurafenib driving epigenetic reprogramming to a drug-resistant state in melanoma [110] and chemotherapy enriching a CD24highCD4high drug-resistant population in breast cancer cells [79].