Xu et al. (2010) reported that a mutation in Archain 1 resulted in a diluted coat color and Purkinje cell degeneration. The occurrence of cutaneous melanoma, a malignant cancer, is strongly associated with mutations in pigmentation-related genes; thus, coat color mutant pigs could be effective models for studying melanomas (Eggermont et al., 2014). Here, ARCN1 is linked to melanoma.