SMAD3 and hepatocellular carcinoma: To test this hypothesis, we evaluated the associations of potential functional SNPs in 16 main cell cycle pathway genes (CDC25C, CDC7, CDKN1A, CDKN2A, CHEK1, MCM4, MCM7, MYC, ORC6L, KAT2B, PLK1, RAD21, RBL2, SMAD3, TGFB3, and YWHAB) with clinical outcomes of 271 HCC cases who had undergone radical surgery resection.