Secondly, the significance of RBL2 rs3929 and SMAD3 rs11556090 in the prognosis of HCC has been demonstrated in this study, however, it still lack epidemiology validation and biological mechanism confirmation, besides the significant eQTL results for RBL3 rs3929 from the GTEx project. This evidence concerns the gene SMAD3 and hepatocellular carcinoma.