This analysis of an independent patient cohort confirmed an increase expression of miR-34a in RA PB CD1c+ compared to age-matched healthy donors PB cells, and revealed that the highest fold change in PB and synovial tissue was among patients resistant-to-treatment and positively correlated with disease duration (r=0.543; P=0.016; Pearson Correlation Coefficient). Here, CD1C is linked to rheumatoid arthritis.