In contrast, soluble AXL was upregulated in the naive-to-treatment and resistant-to-treatment RA groups compared to healthy donors (P=0007 and 0.0042, respectively; Kruskal–Wallis with Dunn’s multiple comparison test), with the highest concentration of sAXL detected in the naive-to-treatment group. This evidence concerns the gene AXL and rheumatoid arthritis.