Similarly, the mRNA of other HIF-1 targets such as LOXL2, PGK1, VEGFA and GLUT1 were also significantly elevated in human OSCC25, invasive ductal breast carcinoma28, colon and rectal adenocarcinoma that highly express LncHIFCAR, but not HIF1A mRNA (Table 2). The gene discussed is LOXL2; the disease is rectum adenocarcinoma.