We found that LncHIFCAR is highly elevated in oral cancer, and that the LncHIFCAR-dependent activation of HIF-1 modulates target genes expression and thereby confers metabolic reprogramming and a hypoxic proliferation advantage required in several tumour progression steps including sphere-forming ability and metastatic colonization capability (Fig. 6g). The gene discussed is HIF1A; the disease is lip and oral cavity carcinoma.