Given the critical role of hypoxic signalling in the formation of a premetastatic niche essential for tumour colonization at the distant site1, 2, we propose that LncHIFCAR-mediated difference in colonization ability is a combined effect of enhanced HIF-1 signalling activation and increased hypoxic tumour cell growth advantage conferred by this lncRNA. Here, HIF1A is linked to neoplasm.