With regards to the whole cohort that is inclusive of Braak NFT stage 0–VI and Thal Aβ Phases 1–5, we examined correlations of WML measures of calpain2, MAG, PLP and MAG:PLP with pathological measures of cortical neurodegenerative AD-pathologies, SVD and CAA to investigate the pathological relationships of white matter changes. The gene discussed is MAG; the disease is Alzheimer disease.