CD4 and neoplasm: To analyze the influence of DTA-1 treatment on tumor growth and accompanying changes in composition of functionally different subsets in populations of CD4+ T cells infiltrating the tumor (TILs) and different lymph nodes, we used TCRmini mice (Kuczma et al. 2009; Pacholczyk et al. 2006) bearing B16 melanoma genetically engineered to express the peptide neo-antigen Ep63K (B16-Ep63K).