TNFRSF18 and neoplasm: In vivo stimulation of glucocorticoid-induced TNF family-related receptor (GITR) elicits an array of T cell responses ranging from proliferation to apoptosis (Ephrem et al. 2013) and results in a potent anti-tumor response to established tumors including murine B16 melanoma (Ramirez-Montagut et al. 2006; Turk et al. 2004).