For example, in a number of solid tumor models, it was shown that the anti-GITR monoclonal antibody (mAb) targeted tumor infiltrating but not peripheral Tregs suggesting that local inflammation sensitizes these cells to DTA-1 mediated inactivation/depletion (Hindley et al. 2011; Sainz-Perez et al. 2012). The gene discussed is TNFRSF18; the disease is neoplasm.