PRRT2 and infection: Atypical DAG- and Ca2+-independent PKC isoforms (e.g., PKC- ζ) have also previously been implicated in phagosomal escape and intracellular survival of Listeria and Plasmodium sporozoites, suggesting that Ca2+-independent novel and atypical PKC isoforms can mediate intracellular pathogen infection (Prudencio et al., 2008; Jiwani et al., 2012).