On the other hand, while androgens, including testosterone, can improve insulin sensitivity in males, neither castration (Macotela, Boucher, Tran, & Kahn, 2009) nor depletion of androgens (Varlamov et al., 2012; Yu et al., 2008) leads to obesity or T2DM‐like symptoms in animal models. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.