Among other factors associated with tumor growth are TNF, IL-1, IL-6, IL-8 [C-X-C motif chemokine ligand 8 (CXCL8)], IL-11, IL-17a, IL-22, acute phase proteins, CCL20, PGE2, colony stimulating factor-1 (CSF-1)/macrophage CSF (M-CSF), vascular endothelial growth factor (VEGF), and granulocyte-macrophage CSF (GM-CSF) (81–86). This evidence concerns the gene VEGFA and neoplasm.