Tumor necrosis factor α and IL-1α were also reported to be released in H446 lung cancer cells after irradiation with γ-rays (8 Gy), but only TNF-α after irradiation with accelerated carbon ions (290 MeV/n, LET 13 keV/μm, 2 Gy) (99). This evidence concerns the gene TNF and lung carcinoma.